Fluorescence Imaging/Agents in Tumor Resection

Fluorescence-guided resection of gliomas.

INTRODUCTION Malignant gliomas remain associated with a poor prognosis despite both surgical treatment and radiochemotherapy.Previous studies have shown that complete resection of contrast-enhancing tumours is achieved in less than 20-30% of patients. 5-aminolevulinic acid (5-ALA) is a pro-drug that leads to accumulation of fluorescent protoporphyrins in malignant gliomas. The fluorescence can ...

Submucosal Endoscopic Tumor Resection

Intraoperative Fluorescence Imaging for Personalized Brain Tumor Resection: Current State and Future Directions

INTRODUCTION Fluorescence-guided surgery is one of the rapidly emerging methods of surgical "theranostics." In this review, we summarize current fluorescence techniques used in neurosurgical practice for brain tumor patients as well as future applications of recent laboratory and translational studies. METHODS Review of the literature. RESULTS A wide spectrum of fluorophores that have been ...

Spinopelvic tumor resection and reconstruction.

How are spinopelvic tumor resections classified? The type of pelvic resection depends on the area involved and the extent of the tumor. Problems arise when the tumor involves the sacrum and the lower lumbar spine. To obtain acceptable surgical margins in these cases, skeletal resection should extend beyond the standard hemipelvectomy (ie, the sacroiliac joint) and may include the ilium, part of...

Image-Guided Brain Tumor Resection

Surgical treatment of primary brain tumors remains a considerable challenge for the neurosurgeon. Nonetheless, surgery is the mainstay of glioma therapy because it provides the means of obtaining absolute tissue diagnosis, mapping tumor margins, mechanical cytoreduction, and guidance of adjuvant therapy such as brachytherapy, gene therapy, or radiosurgery. Recent developments in computation tec...